CD 10899

CD 10899 is a hydroxylated metabolite of Volasertib (HY-12137) . CD 10899 is pharmacologically active against Polo-like kinase 1 (PLK1) (IC50: 6 nM) . Volasertib is an orally active, highly potent and ATP-competitive PLK1 inhibitor. CD 10899 can be used for research of cancer[1].

Product Specifications

CAS Number

[1331770-20-7]

UNSPSC

12352005

Target

Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cd-10899.html

Solubility

10 mM in DMSO

Smiles

CC(N1C2=NC(NC3=C(C=C(C=C3)C(N[C@H]4CC[C@H](N5CCN(CC5)CC6CC6)CC4)=O)OC)=NC=C2N(C(C1(O)CC)=O)C)C

Molecular Formula

C34H50N8O4

Molecular Weight

634.81

References & Citations

[1]Lang I, et al. Potential Drug-Drug Interactions with Combination Volasertib + Itraconazole: A Phase I, Fixed-sequence Study in Patients with Solid Tumors. Clin Ther. 2020 Nov;42 (11) :2214-2224.