Cosdosiran

Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.

Product Specifications

CAS Number

[1834560-88-1]

Product Name Alternative

QPI-1007

UNSPSC

12352208

Target

Caspase; Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Apoptosis; Epigenetics

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cosdosiran.html

Purity

98.48

Solubility

10 mM in H2O

Smiles

[Cosdosiran]

References & Citations

[1]Solano EC, Kornbrust DJ, Beaudry A, Foy JW, Schneider DJ, Thompson JD. Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection. Nucleic Acid Ther. 2014;24 (4) :258-266. doi:10.1089/nat.2014.0489