Anti-inflammatory agent 74

Anti-inflammatory agent 74 (B5) is an anti-inflammatory agent that can inhibit NO, IL-6, and TNF-α, with IC50 values of 10.88 μM and 4.93 μM for NO and IL-6, respectively. Anti-inflammatory agent 74 alleviates acute lung injury (ALI) by regulating inflammatory mediators and inhibiting the MAPK and NF-κB signaling pathways[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Interleukin Related; NF-κB; p38 MAPK; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-74.html

Solubility

10 mM in DMSO

Smiles

[H][C@]12CO[C@H]([C@]1(CO[C@@H]2C3=CC=C(C(OC)=C3)O[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)COC([C@@H](NC(OC(C)(C)C)=O)CC5=CC=CC=C5)=O)[H])C6=CC=C(C(OC)=C6)OC

Molecular Formula

C41H51NO14

Molecular Weight

781.84

References & Citations

[1]Guo Hong-Yan, et al. "Design and synthesis of forsythin derivatives as anti-inflammatory agents for acute lung injury." European Journal of Medicinal Chemistry (2024) : 116223.