β-Glucuronidase-IN-4
EcGUS-IN-1 (Compound E-9) is a non-competitive β-glucuronidase inhibitor, with an IC50 of 2.68 μM and a Ki value of 1.64 μM. EcGUS-IN-1 can improve gastrointestinal adverse events (GIAE) caused by Escherichia coli infection by inhibiting E. coli β-glucuronidase activity[1].
Product Specifications
CAS Number
2208619-76-3
UNSPSC
12352211
Target
β-glucuronidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ecgus-in-1.html
Smiles
S=C(NC1=CC=C(C(F)(F)F)C=C1)NC2=CC=C(N=CN3)C3=C2
Molecular Formula
C15H11F3N4S
Molecular Weight
336.33
References & Citations
[1]Xu K, et al. Design, synthesis, and biological evaluation of (thio) urea derivatives as potent Escherichia coli β-glucuronidase inhibitors. J Enzyme Inhib Med Chem. 2024 Dec;39 (1) :2387415.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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