SMD-3040 intermediate-2
SMD-3040 intermediate-2 is an intermediate in the synthesis of SMD-3040. SMD-3040 contains SMARCA2/4 ligands, linker and VHL ligands and is a selective SMARCA2 degrader. MD-3040 can be used for ADC drug synthesis and has strong tumor growth inhibition in tumor xenograft models[1].
Product Specifications
CAS Number
2632308-00-8
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Drug Intermediate
Type
ADC Related
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smd-3040-intermediate-2.html
Purity
95.82
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(N2CC3(CC2C)CCN(CC3)C(OC(C)(C)C)=O)C=C1Cl
Molecular Formula
C21H28ClN3O2
Molecular Weight
389.92
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang L, et.al. Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. J Med Chem. 2023 Jul 31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Mouse Monoclonal DBC1/p30 Antibody (PCRP-KIAA1967-1D10) [Janelia Fluor 646]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NBP3-24324JF646 0.1 mL
Mouse Monoclonal DBC1/p30 Antibody (PCRP-KIAA1967-1D10) [Janelia Fluor 646]
Sign In for Pricing
View Details 
MR206827L4V 200 µL
Rnf128 (NM_023270) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details orb1669451-01 48 Tests
Mouse Phosphinothricin acetyltransferase (PAT) ELISA Kit
Sign In for Pricing
View Details orb1669451-02 96 Tests
Mouse Phosphinothricin acetyltransferase (PAT) ELISA Kit
Sign In for Pricing
View Details 
MF-201-14-C57 10 Slides
Mouse C57 Caudal cerebellum/M oblangata Coronal Frozen Sections Reg.14
Sign In for Pricing
View Details