Roluperidone
Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively) .
Product Specifications
CAS Number
[359625-79-9]
Product Name Alternative
CYR-101; MIN-101; MT-210
UNSPSC
12352005
Target
5-HT Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CYR-101.html
Purity
99.86
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1N(CC2CCN(CC(C3=CC=C(F)C=C3)=O)CC2)CC4=C1C=CC=C4
Molecular Formula
C22H23FN2O2
Molecular Weight
366.43
References & Citations
[1]Davidson M, et al. Efficacy and Safety of MIN-101: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of a New Drug in Development for the Treatment of Negative Symptoms in Schizophrenia. Am J Psychiatry. 2017 Jul 28:appiajp201717010122.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT2 Receptor; α-1 microglobulin
Available Sizes
Curated Selection
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