Recombinant Human HspA9
Recombinant Human HspA9
Product Specifications
Product Name Alternative
Hsp70 protein 9
Gene Name
HSPA9
UniProt
P38646
Cellular Locus
Mitochondrion , Nucleus, nucleolus
Reactivity
Human
Target Antigen
Stress-70 protein, mitochondrial
Target
HspA9
Type
Protein
Applications
WB
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Form
Liquid
Buffer
20 mM Tris
Function
Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity). {UniProtKB:P38647, PubMed:21123823, PubMed:26702583}.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below - 20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA is recommended for long-term storage.
Product Datasheet
https://www.qedbio.com/wp-content/uploads/pdf/11118P.pdf
Specificity
HspA9
Formulation
Sterile-filtered colorless solution in 20mM Tris-Hcl, pH 8.0, 0.5mM DTT and 10% glycerol.
Buffer pH
pH 8.0
Target Background
HspA9, a memer of the Hsp70 family, encodes a heat-shock cognate protein that is involved in the control of cell proliferation and acts as a chaperone. HspA9 is located on chromosome 5, band q31, a region thatis often deleted in myeloid leukemias and myelodysplasia, making it a candidate tumor suppressor gene. HspA9 suppresses nuclear translocation, transcriptional activation, and control centrosome-duplication functions of p53.
CAS Number
9000-83-3
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