CDK4-CCND3, Human (sf9, GST, His)

CDK4 protein, acting as a Ser/Thr kinase in the cyclin D-CDK4 complex, critically regulates the G (1) /S transition by phosphorylating and inhibiting RB family members. This activity, specifically hypophosphorylation of RB1 during early G (1) phase, releases E2F and promotes transcription of genes that drive G (1) progression. CDK4-CCND3 Protein, Human (sf9, GST, His) is the recombinant human-derived CDK4-CCND3, expressed by Sf9 insect cells, with N-His, N-GST labeled tag.