Scoulerine

Scoulerine ((-) -Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (β-site amyloid precursor protein cleaving enzyme 1) . Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells[1].

Product Specifications

CAS Number

[6451-73-6]

Product Name Alternative

(-) -Scoulerine; Discretamine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Beta-secretase; Microtubule/Tubulin

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/scoulerine.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(OC)C=C(CCN2CC3=C(O)C(OC)=CC=C3C[C@]24[H])C4=C1

Molecular Formula

C19H21NO4

Molecular Weight

327.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Habartova K, et al. Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci Rep. 2018;8 (1) :4829. Published 2018 Mar 19.