AVP-13358
AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E (IgE) -mediated immune responses, with IC50 values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of IL-4, IL-5, and IL-13. It also targets other markers critical for the development of allergic responses, including the B cell IgE receptor (CD23) in human monocytes and the CD23 and IL-4 receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses[1].
Product Specifications
CAS Number
459805-03-9
UNSPSC
12352005
Target
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/avp-13358.html
Smiles
O=C(C1=CC=C2N=C(C3=CC=C(NC(C45CC6CC(C5)CC(C4)C6)=O)C=C3)NC2=C1)NC7=NC=CC=C7
Molecular Formula
C30H29N5O2
Molecular Weight
491.58
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-13; IL-4; IL-5
Available Sizes
Frequently Asked Questions
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