2-Chloro-6-methoxypurine riboside

2-Chloro-6-methoxypurine riboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly (ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

Product Specifications

CAS Number

[15465-92-6]

Product Name Alternative

2-Chloro-6-O-methyl-inosine

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Nucleoside Antimetabolite/Analog; Xanthine Oxidase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-chloro-6-methoxypurine-riboside.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(Cl)N=C3OC)=C3N=C2)O1

Molecular Formula

C11H13ClN4O5

Molecular Weight

316.70

Precautions

P264-P270-P280-P302+P352-P330-P362+P364-P501

References & Citations

[1]Virág L, Szabó C. Purines inhibit poly (ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15 (1) :99-107.|[2]Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23 (2) :143-50.