P-gp inhibitor 27

P-gp inhibitor 27 (Compound D2) is an inhibitor for P-glycoprotein (P-gp), that downregulates the expression of P-gp and MRP1, increases the Rh123 accumulation in A2780/T cell, and reverses multidrug resistance to Paclitaxel (HY-B0015) (EC50 is 88 nM) and Cisplatin (HY-17394) [1].

Product Specifications

UNSPSC

12352211

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p-gp-inhibitor-27.html

Smiles

COC1=CC(C2=CC=C(CNC(C3=CN(C)C4=C3C=CC=C4)=O)N=C2)=CC(OC)=C1OC

Molecular Formula

C25H25N3O4

Molecular Weight

431.48

References & Citations

[1]Peng YY, et al., Design, synthesis and biological evaluation of biaryl amide derivatives as modulators of multi-drug resistance. Eur J Med Chem. 2025 Jan 15;282:117090.