P-gp inhibitor 27
P-gp inhibitor 27 (Compound D2) is an inhibitor for P-glycoprotein (P-gp), that downregulates the expression of P-gp and MRP1, increases the Rh123 accumulation in A2780/T cell, and reverses multidrug resistance to Paclitaxel (HY-B0015) (EC50 is 88 nM) and Cisplatin (HY-17394) [1].
Product Specifications
UNSPSC
12352211
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-27.html
Smiles
COC1=CC(C2=CC=C(CNC(C3=CN(C)C4=C3C=CC=C4)=O)N=C2)=CC(OC)=C1OC
Molecular Formula
C25H25N3O4
Molecular Weight
431.48
References & Citations
[1]Peng YY, et al., Design, synthesis and biological evaluation of biaryl amide derivatives as modulators of multi-drug resistance. Eur J Med Chem. 2025 Jan 15;282:117090.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6368631-01 0.1 mL
ACP6 (Lysophosphatidic Acid Phosphatase Type 6, Acid Phosphatase 6, Lysophosphatidic, Acid Phosphatase-like Protein 1, PACPL1, ACPL1, LPAP, UNQ205/PRO231) (MaxLight 405)
Ask
View Details MBS6368631-02 5x 0.1 mL
ACP6 (Lysophosphatidic Acid Phosphatase Type 6, Acid Phosphatase 6, Lysophosphatidic, Acid Phosphatase-like Protein 1, PACPL1, ACPL1, LPAP, UNQ205/PRO231) (MaxLight 405)
Ask
View Details 
036874-ML550 100 µL
IER5, ID (IER5, Immediate early response gene 5 protein) (MaxLight 550) discontinued
Ask
View Details