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2'-Deoxyadenosine monohydrate-13C10,15N5 (hydrate)

2'-Deoxyadenosine monohydrate-13C10,15N5 is the 13C and 15N labeled 2'-Deoxyadenosine monohydrate. 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer[2][3][4].

Product Specifications

CAS Number

2483830-27-7

UNSPSC

12352005

Target

Apoptosis; Caspase; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-deoxyadenosine-monohydrate-13c10-15n5-hydrate.html

Purity

99.7

Solubility

10 mM in DMSO

Smiles

[15NH2][13C]1=[15N][13CH]=[15N][13C]2=[13C]1[15N]=[13CH][15N]2[13C@H]3[13CH2][13C@H](O)[13C@@H]([13CH2]O)O3.O

Molecular Formula

13C10H15 15N5O4

Molecular Weight

284.15

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Iain L. Campbell, et al. Effects of adenosine, 2-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism. Biochem J (1982) 204 (3) : 689-696.|[3]Giannecchini M, et al. 2'-Deoxyadenosine causes apoptotic cell death in a human colon carcinoma cell line. J Biochem Mol Toxicol. 2003;17 (6) :329-37.|[4]Cass CE, et al. Effects of 2'-deoxyadenosine, 9-beta-D-arabinofuranosyladenine, and related compounds on S-adenosyl-L-homocysteine hydrolase activity in synchronous and asynchronous cultured cells. Cancer Res. 1982 Dec;42 (12) :4991-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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