CIDD-0072424
CIDD-0072424 selectively inhibits Protein Kinase C-epsilon (PKCε) (Ki=54 nM) . CIDD-0072424 reduces ethanol consumption and preference in a dose-dependent manner[1].
Product Specifications
CAS Number
1620195-03-0
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cidd-0072424.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]([C@]1([H])CC[C@@](CC1)([H])C(NC2=CC=NC=C2)=O)CNC(C3(CC3)C4=CC=C(C=C4)Cl)=O
Molecular Formula
C24H29ClN4O2
Molecular Weight
440.97
References & Citations
[1]De Kraker H, et al. Asymmetric Synthesis of CIDD-0072424 via an Enantioselective Nitro-Mannich Reaction: A Central Nervous System Penetrant, Selective Small Molecule Inhibitor of Protein Kinase C Epsilon. J Org Chem. 2024 Apr 5;89 (7) :5134-5141.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCε
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