GSK-3β inhibitor 17
GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury[1].
Product Specifications
CAS Number
[2521624-67-7]
UNSPSC
12352005
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-17.html
Smiles
COC(C1=CC=C(S1)S(=O)(NC2=CC=C(C=C2)C3=NC(C4=CC(NC5=CC=C(C=C5)OC(F)(F)F)=NC=C4)=NO3)=O)=O
Molecular Formula
C26H18F3N5O6S2
Molecular Weight
617.58
References & Citations
[1]Cai YT, et al. A novel GSK3β inhibitor 5n attenuates acute kidney injury. Heliyon. 2024 Apr 12;10 (8) :e29159.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
Explore Other Products
Browse additional items from our catalog
![Mouse Monoclonal Ret Antibody (RET/2795) [HRP]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
