GSK-3β inhibitor 17
Product Specifications
UNSPSC Description
GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury[1].
Target Antigen
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR;Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-17.html
Smiles
COC(C1=CC=C(S1)S(=O)(NC2=CC=C(C=C2)C3=NC(C4=CC(NC5=CC=C(C=C5)OC(F)(F)F)=NC=C4)=NO3)=O)=O
Molecular Weight
617.58
References & Citations
[1]Cai YT, et al. A novel GSK3β inhibitor 5n attenuates acute kidney injury. Heliyon. 2024 Apr 12;10(8):e29159.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163748/GSK-3β-inhibitor-17-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163748/
Clinical Information
No Development Reported
CAS Number
2521624-67-7
Curated Selection
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