PI3K-IN-30

PI3K-IN-30 (compound 6d) is a potent PI3K inhibitor with IC50s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively[1].

Product Specifications

CAS Number

[2281803-22-1]

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-in-30.html

Purity

98.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COCCN(CCO)C1=NC(N2C3=CC=CC=C3N=C2C(F)F)=NC(N4CCOCC4)=N1

Molecular Formula

C20H25F2N7O3

Molecular Weight

449.45

References & Citations

[1]Van Dort ME, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022;229:113996.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Available Sizes

Curated Selection

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