20α-Dihydroprogesterone

20α-Dihydroprogesterone is the metabolite of Progesterone (HY-N0437) . 20α-Dihydroprogesterone inhibits cell proliferation and migration in breast tissue. 20α-Dihydroprogesterone inhibits aromatase in cell MCF-7aro with IC50 about 5 μM[1].

Product Specifications

CAS Number

[145-14-2]

Product Name Alternative

20-OH-P

UNSPSC

12352211

Hazard Statement

H351, H360

Target

Cytochrome P450; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/20α-dihydroprogesterone.html

Purity

98.07

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@@H](O)C)C

Molecular Formula

C21H32O2

Molecular Weight

316.48

Precautions

H351, H360

References & Citations

[1]Pasqualini JR, et al., The anti-aromatase effect of progesterone and of its natural metabolites 20alpha- and 5alpha-dihydroprogesterone in the MCF-7aro breast cancer cell line. Anticancer Res. 2008 Jul-Aug;28 (4B) :2129-33.