ABM-14
ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 (HY-130492) to degrade AR[1].
Product Specifications
CAS Number
[1973408-76-2]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/abm-14.html
Purity
98.17
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(N(C(N(C2=CC=C(C3=CC=C(O)C=C3)C=C2)C4(C)C)=S)C4=O)C=C1C(F)(F)F
Molecular Formula
C25H18F3N3O2S
Molecular Weight
481.49
References & Citations
[1]Meizhong Jin, et al. Compounds and methods for the targeted degradation of the androgen receptor. WO2016118666A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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