(S) -AL-8810

(S) -AL 8810 is an 11β-fluoro analog of PGF2α that acts as a potent and selective antagonist at the FP receptor. (S) -AL 8810 is the C-15 epimer of AL 8810, having the inverse, (S), or "natural" configuration at C-15 relative to AL 8810, which is 15- (R) [1].

Product Specifications

CAS Number

[1224444-55-6]

UNSPSC

12352005

Hazard Statement

H302-H360

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/s-al-8810.html

Solubility

10 mM in DMSO

Smiles

O[C@@H](C1CC2=CC=CC=C2C1)/C=C/[C@@H]3[C@H]([C@H](C[C@@H]3F)O)C/C=C\CCCC(O)=O

Molecular Formula

C24H31FO4

Molecular Weight

402.50

Precautions

P264-P270-P280-P330-P405-P501

References & Citations

[1]Griffin BW, Klimko P, Crider JY, Sharif NA. AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther. 1999 Sep;290 (3) :1278-84.