KU-0058684

KU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair[1][2].

Product Specifications

CAS Number

[623578-11-0]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ku-0058684.html

Smiles

O=C(N1C2=CC(CC3=NNC(C4=C3C=CC=C4)=O)=CC=C2F)CCC1=O

Molecular Formula

C19H14FN3O3

Molecular Weight

351.33

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Mitchell J, et al. Poly (ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75 (5) :1520-7.|[2]McCabe N, et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency. Cancer Biol Ther. 2005 Sep;4 (9) :934-6.