11-Deoxyprostaglandin F2α
11-Deoxyprostaglandin F2α is an activator for TREK-2 channels with EC50 of 0.294 μM. 11-Deoxyprostaglandin F2α inhibits the K2P channel TREK-1[1].
Product Specifications
CAS Number
[37786-06-4]
UNSPSC
12352211
Hazard Statement
H225-H319-H336-H360
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/11-deoxyprostaglandin-f2α.html
Solubility
10 mM in DMSO
Smiles
OC(CCC/C=C\C[C@@H]1[C@H](CC[C@@H]1O)/C=C/[C@@H](O)CCCCC)=O
Molecular Formula
C20H34O4
Molecular Weight
338.48
Precautions
P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501
References & Citations
[1]Dadi PK, et al., Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx. ACS Chem Neurosci. 2017 Mar 15;8 (3) :558-568.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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