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BRD-K20733377

BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide -induced IMR-90 senescent cell with an IC50 of 10.7 μM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model[1].

Product Specifications

CAS Number

452350-43-5

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/brd-k20733377.html

Concentration

10mM

Purity

99.50

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(C=C1)C2=CC=CC=C2)NC3=CC=C(C=C3)S(=O)(NC4=NC=CC=N4)=O

Molecular Formula

C23H18N4O3S

Molecular Weight

430.48

References & Citations

[1]Wong F, et al., Discovering small-molecule senolytics with deep neural networks. Nat Aging. 2023 Jun;3 (6) :734-750.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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