BRD-K20733377
BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide (HY-13629) -induced IMR-90 senescent cell with an IC50 of 10.7 μM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model[1].
Product Specifications
CAS Number
[452350-43-5]
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/brd-k20733377.html
Concentration
10mM
Purity
99.50
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C=C1)C2=CC=CC=C2)NC3=CC=C(C=C3)S(=O)(NC4=NC=CC=N4)=O
Molecular Formula
C23H18N4O3S
Molecular Weight
430.48
References & Citations
[1]Wong F, et al., Discovering small-molecule senolytics with deep neural networks. Nat Aging. 2023 Jun;3 (6) :734-750.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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