(R) -Merimepodib

(R) -Merimepodib is the isomer of Merimepodib (HY-13986), and can be used as an experimental control. Merimepodib (VX-497) is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.

Product Specifications

CAS Number

[2748420-50-8]

Product Name Alternative

(R) -VX-497; (R) -MMPD

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

IMPDH

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/r-merimepodib.html

Purity

96.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(C2=CN=CO2)C=CC(NC(NC3=CC(CNC(O[C@@H]4CCOC4)=O)=CC=C3)=O)=C1

Molecular Formula

C23H24N4O6

Molecular Weight

452.46

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jain J, et al. VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90 (5) :625-37.|[2]Decker CJ, et al. The novel IMPDH inhibitor VX-497 prolongs skin graft survival and improves graft versus host disease in mice. Drugs Exp Clin Res. 2001;27 (3) :89-95.|[3]Markland W, et al. Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon. Antimicrob Agents Chemother. 2000 Apr;44 (4) :859-66.