Ferritin, Light Chain (FTL) (Microglia Marker) (FTL/1388), 0.2mg/mL
Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III) . Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Product Specifications
Synonyms
Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light polypeptide; FTL; LFTD; NBIA3
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
FTL
Gene ID
2512
NCBI Gene ID
433670
UniProt
P02792
Swiss Prot
P02792
Host
Mouse
Species Reactivity
Human
Reactivity
Ferritin, Light Chain
Immunogen
Recombinant human FTL protein fragment (aa 38-165) (exact sequence is proprietary)
Target Antigen
Ferritin, Light Chain
Clonality
Monoclonal
Clone
FTL/1388
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified) |WB (verified)
Field of Research
Metabolism
Positive Control
HepG2, HeLa, HL-60 or 293T cells. Pancreas, Liver, Cerebellum or Testis.
Stability
2 years
Concentration
0.2 mg/mL
Buffer
PBS, 0.05% BSA, 0.05% azide
Molecular Weight
19-25 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Product Datasheet
https://cdn.gentaur.com/products/37/905287/datasheet/bnub1388-500.pdf
Product MSDS
https://cdn.gentaur.com/products/37/68dd029b061270361e101ef1/msds/bnub1388-500.pdf
Fragment
IgG2a
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
CAS Number
9007-83-4
Conjugate
Purified, with BSA
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