S 17092

S 17092 (S 17092-1) is an orally active cerebral prolyl-endopeptidase (PEP) inhibitor with an IC50 of 1.2 nM. S 17092 inhibits cell apoptosis. S 17092 mechanism of action is to inhibit the activity of PEP, slowing down the degradation of neuroactive peptides and thus enhancing memory function. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging[1][2][3].

Product Specifications

CAS Number

[176797-26-5]

Product Name Alternative

S 17092-1

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Prolyl Endopeptidase (PREP)

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-17092.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C([C@H]1[C@@](C2=CC=CC=C2)([H])C1)N3[C@]4([H])[C@](CCCC4)([H])C[C@H]3C(N5CCSC5)=O

Molecular Formula

C22H28N2O2S

Molecular Weight

384.53

Precautions

H302

References & Citations

[1]Philippe Morain, et al. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies. CNS Drug Rev. Spring 2002;8 (1) :31-52.|[2]Odaka C, et al. Murine T cells expressing high activity of prolyl endopeptidase are susceptible to activation-induced cell death. FEBS Lett. 2002 Feb 13;512 (1-3) :163-7.|[3]Di Daniel E, et al. Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity. Mol Cell Neurosci. 2009 Jul;41 (3) :373-82.