ERα degrader 9
ERα degrader 9 is a dual targeting ligand for estrogen receptor α (ERα) and aromatase (ARO). ERα degrader 9 can be utilized for synthesis of PROTAC ERα Degrader-9.
Product Specifications
UNSPSC
12352005
Target
Cytochrome P450; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erα-degrader-9.html
Smiles
OC1=CC=C(C2=C([C@@H]3C(C[C@H]2O3)S(N(CC(F)(F)F)C4=CC=C(C=C4)O)(=O)=O)C5=CC=C(C=C5)N6C=CN=C6)C=C1
Molecular Formula
C29H24F3N3O5S
Molecular Weight
583.58
References & Citations
[1]Xin L, et al., Discovery of Novel ERα and Aromatase Dual-Targeting PROTAC Degraders to Overcome Endocrine-Resistant Breast Cancer. J Med Chem. 2024 Jun 13;67 (11) :8913-8931.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aromatase/CYP19A1; ERα
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