K-111
K-111 (BM-170744) is an oral active PPAR alpha agonist. K-111 show efficacy in improving insulin resistance, reducing body weight, and ameliorating atherogenic dyslipidemia. K-111 can be used for study of type 2 diabetes, dyslipidaemia, obesity and the metabolic syndrome[1][2].
Product Specifications
CAS Number
221564-97-2
Product Name Alternative
BM 17.0744
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/k-111.html
Smiles
O=C(C(Cl)(CCCCCCCCCCC1=CC=C(C=C1)Cl)Cl)O
Molecular Formula
C18H25Cl3O2
Molecular Weight
379.75
References & Citations
[1]Schäfer SA, et al. Biochemical and morphological effects of K-111, a peroxisome proliferator-activated receptor (PPAR) alpha activator, in non-human primates. Biochem Pharmacol. 2004;68 (2) :239-251. |[2]Ortmeyer HK, et al. Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeys. Am J Physiol Regul Integr Comp Physiol. 2005;288 (6) :R1509-R1517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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