GYKI 53655 (hydrochloride)

GYKI 53655 (LY300168) hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonist.

Product Specifications

CAS Number

[143692-48-2]

Product Name Alternative

LY300168 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/GYKI53655_hydrochloride.html

Purity

98.37

Solubility

DMSO : ≥ 160 mg/mL|H2O : 8 mg/mL (ultrasonic; warming)

Smiles

O=C(N1N=C(C2=CC=C(N)C=C2)C3=CC(OCO4)=C4C=C3CC1C)NC.[H]Cl

Molecular Formula

C19H21ClN4O3

Molecular Weight

388.85

Precautions

H301

References & Citations

[1]Bleakman D, et al. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology. 1996;35 (12) :1689-702.|[2]Chizh BA, et al. A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord. Br J Pharmacol. 1994 Jul;112 (3) :843-6.|[3]Szabados T, et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res Bull. 2001 Jun;55 (3) :387-91.