Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Oritavancin

Oritavancin (LY 333328), a semisynthetic derivative of Vancomycin , is an orally active glycopeptide antibiotic with bactericidal activity against gram-positive organisms. Oritavancin shows antibacterial effect against B. anthracis, such as Ames strain with a MIC value of 0.015 g/mL. Oritavancin inhibits cell wall synthesis and disrupts the membrane potential. Oritavancin inhibits ArlS kinase activity thereby interfering the signal transduction. Oritavancin enters cells by adsorptive endocytosis, which drives it to lysosomes, where it exerts antibiotic activity[1][2][3][4][5].

Product Specifications

CAS Number

171099-57-3

Product Name Alternative

LY 333328; Orbactiv

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oritavancin.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@@H](O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@]2(C)NCC3=CC=C(C4=CC=C(Cl)C=C4)C=C3)[C@@H](O[C@H](CO)[C@H]1O)OC5=C(OC6=CC=C([C@H]([C@H]7NC([C@H](NC)CC(C)C)=O)O)C=C6Cl)C=C([C@](NC([C@@H](NC7=O)CC(N)=O)=O)([H])C(N[C@](C8=O)([H])C9=CC%10=C(O)C=C9)=O)C=C5OC%11=CC=C([C@H]([C@](C(N[C@@](C(O)=O)([H])C%12=C%10C(O)=CC(O)=C%12)=O)([H])N8)O[C@@](O[C@@H](C)[C@@H]%13O)([H])C[C@@]%13(N)C)C=C%11Cl

Molecular Formula

C86H97Cl3N10O26

Molecular Weight

1793.10

References & Citations

[1]Coyle EA, et al. Activity of oritavancin (LY333328), an investigational glycopeptide, compared to that of vancomycin against multidrug-resistant Streptococcus pneumoniae in an in vitro pharmacodynamic model. Antimicrob Agents Chemother. 2001 Mar;45 (3) :706-9.|[2]Arhin FF, et al. Effect of polysorbate 80 on oritavancin binding to plastic surfaces: implications for susceptibility testing. Antimicrob Agents Chemother. 2008 May;52 (5) :1597-603. |[3]Bai J, et al. The role of ArlRS in regulating oxacillin susceptibility in methicillin-resistant Staphylococcus aureus indicates it is a potential target for antimicrobial resistance breakers[J]. Emerg Microbes Infect. 2019;8 (1) :503-515.|[4]Van Bambeke F, et al. Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages[J]. Antimicrob Agents Chemother. 2004 Aug;48 (8) :2853-60.|[5]Heine HS, et al. Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthrax. Antimicrob Agents Chemother. 2008 Sep;52 (9) :3350-7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Glycopeptide

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Bromodeoxyuridine (BrdU)
B2850-01 1 g

Bromodeoxyuridine (BrdU)

Sign In for Pricing
View Details
Bromodeoxyuridine (BrdU)
B2850-02 5 g

Bromodeoxyuridine (BrdU)

Sign In for Pricing
View Details
Bromodeoxyuridine (BrdU)
B2850-03 10 g

Bromodeoxyuridine (BrdU)

Sign In for Pricing
View Details
Bromodeoxyuridine (BrdU)
B2850-04 25 g

Bromodeoxyuridine (BrdU)

Sign In for Pricing
View Details
S100-A8/A9 Rabbit pAb, Pacific Blue conjugated
orb2847361 100 µL

S100-A8/A9 Rabbit pAb, Pacific Blue conjugated

Sign In for Pricing
View Details
Recombinant Bacillus halodurans UPF0637 protein BH2637 (BH2637)
MBS1481043-01 0.02 mg (E-Coli)

Recombinant Bacillus halodurans UPF0637 protein BH2637 (BH2637)

Sign In for Pricing
View Details