8-Azanebularine
Product Specifications
UNSPSC Description
8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction[1].
Target Antigen
Adenosine Deaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/8-azanebularine.html
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC=C3N=N2
Molecular Weight
253.21
References & Citations
[1]Haudenschild BL, et al. A transition state analogue for an RNA-editing reaction. J Am Chem Soc. 2004;126(36):11213-11219.|[2]Mendoza HG, et al. Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes. Biochemistry. 2023 Apr 18;62(8):1376-1387.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145442/8-Azanebularine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145442/8-Azanebularine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
38874-46-3
Available Sizes
Curated Selection
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