8-Azanebularine
8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM) . 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM) . 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction[1].
Product Specifications
CAS Number
[38874-46-3]
UNSPSC
12352005
Target
Adenosine Deaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/8-azanebularine.html
Purity
99.33
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC=C3N=N2
Molecular Formula
C9H11N5O4
Molecular Weight
253.21
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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