8-Azanebularine

8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM) . 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM) . 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction[1].

Product Specifications

CAS Number

[38874-46-3]

UNSPSC

12352005

Target

Adenosine Deaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/8-azanebularine.html

Purity

99.33

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC=C3N=N2

Molecular Formula

C9H11N5O4

Molecular Weight

253.21

References & Citations

[1]Haudenschild BL, et al. A transition state analogue for an RNA-editing reaction. J Am Chem Soc. 2004;126 (36) :11213-11219.|[2]Mendoza HG, et al. Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes. Biochemistry. 2023 Apr 18;62 (8) :1376-1387.