Sauchinone

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae) . Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1].

Product Specifications

CAS Number

[177931-17-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sauchinone.html

Purity

99.62

Solubility

DMSO : 22.73 mg/mL (ultrasonic)

Smiles

C[C@@H]([C@@H](C[C@]12[H])C)[C@](C(C=C(OCO3)C3=C4)=C4O5)([H])[C@@]1([H])[C@]5(OCO6)C6=CC2=O

Molecular Formula

C20H20O6

Molecular Weight

356.37

Precautions

H302, H315, H319

References & Citations

[1]Lee AK, et al. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol. 2003 May;139 (1) :11-20.