Cofilin Rabbit Polyclonal Antibody
Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration. Cofilin 1 has been shown to interact with HSPH1 and LIMK1.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
CFL1, CFL
Swiss Prot
P23528 Human, P18760 Mouse, P45592 Rat
Cellular Locus
Nucleus matrix, Cytoplasm, Cytoskeleton, Cell projection.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Monkey
Immunogen
Synthetic peptide within human Cofilin aa 117-166 / 166.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
Concentration
2 mg/mL
Dilution
WB: 1:1,000;IF-Cell: 1:100;FC: 1:200-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 19 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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