TS 155-2
TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis[1][2].
Product Specifications
CAS Number
1314486-37-7
Product Name Alternative
JBIR 100
UNSPSC
12352005
Target
Antibiotic; Bacterial; Proton Pump
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ts-155-2.html
Smiles
O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\C)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(O)=O
Molecular Formula
C39H60O11
Molecular Weight
704.89
References & Citations
[1]Ueda JY, et al. A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species. J Antibiot (Tokyo) . 2010 Oct;63 (10) :627-9.|[2]Molloy EM, et al. Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorg Med Chem. 2016 Dec 15;24 (24) :6276-6290.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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