Goat anti-P53 Polyclonal antibody
Goat polyclonal antibody to P53. This protein reacts to diverse cellular stresses to regulate target genes that induce apoptosis, senescence, cell cycle arrest, DNA repair, or changes in metabolism. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is assumed to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumour suppressor.
Product Specifications
Specifications
Detects endogenous levels of P53 by Western blot and in transfected cells with GFP-P53.
Product Name Alternative
BCC7, LFS1 and TRP53 antibody.
UNSPSC Description
Tumor protein p53
Volume
200 µL
Gene ID
ENSG00000141510
Accession Number
ENSG00000141510
Host
Goat
Antigen Species
Human
Reactivity
Human, mouse, rat, bovine, canine, chicken/avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep, simian, other
Immunogen
Purified recombinant peptide derived from within residues 280 aa to the C-terminus of human P53 produced in E. coli.
Target Antigen
Purified recombinant peptide derived from within residues 280 aa to the C-terminus of human P53 produced in E. coli.
Immunogen Type
Recombinant protein
Target
Anti-P53
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Type
Primary
Sequence
DRRTEEENLRKKGEPHHELPPGSTKRALSNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Applications
WB, IF
Purification
Epitope affinity purified
Concentration
4 mg/mL
Dilution
WB:1:500-1:5,000, IF:1:25-1:250
Form
Buffer
PBS, 20% glycerol and 0.05% sodium azide
References & Citations
1. Alves LS, Marques ARA, Padrao N, et al. J Cell Sci 2021 Sep. PMID: 34528688
Storage Conditions
CAS Number
9007-83-4
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