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Goat anti-HTT ENS Polyclonal antibody

Huntingtin is a protein linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons.

Product Specifications

Specifications

Reacts huntingtin protein, amino acids 85-200. The antibody recognizes wild type and mutant huntingtin.

Product Name Alternative

HD, HTT and IT15 antibody.

UNSPSC Description

Huntingtin

Volume

200 µL

Gene ID

ENSG00000197386

Accession Number

ENSG00000197386

Host

Goat

Antigen Species

Human

Reactivity

Human, mouse, rat, bovine, canine, chicken/avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep, simian, other

Immunogen

Purified recombinant peptide derived from within residues 85 to 200 aa of human HTT produced in E. coli

Target Antigen

Purified recombinant peptide derived from within residues 85 to 200 aa of human HTT produced in E. coli

Immunogen Type

Recombinant protein

Target

Anti-HTT

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Type

Primary

Sequence

PLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAEL

Applications

WB, IF, IHC-P, IHC-F

Purification

Epitope affinity purified

Concentration

3 mg/mL

Dilution

WB:1:500-1:2,000, IF:1:500-1:2,000, IHC-P:1:500-1:2,000, IHC-F:1:500-1:2,000

Form

Polyclonal antibody supplied as a 200 µl (3 mg/mL) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.

Buffer

PBS, 20% glycerol and 0.05% sodium azide

References & Citations

1. Miniarikova J, Zimmer V, Martier R, et al. Gene Ther. 2017 Oct. PMID:28771234, 2. Meunier C, Merienne N, Jollé C, et al. Glia. 2016 Jul. PMID: 27442486, 3. Déglon N, Merienne N, Genome editing for the treatment of huntington's disease, EP 2982758 A1 Patent, 2014

Storage Conditions

For continuous use, store at 2-8 deg;C for one-two days. For extended storage, store in -20 deg;C freezer. Working dilution samples should be discarded if not used within 12 hours.

CAS Number

9007-83-4

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