CINPA1

CINPA1 is a potent and specific inhibitor of constitutive androstane receptor (CAR) that does not activate pregnane X receptor (PXR) . CINPA1 reduces CAR-mediated transcription with an IC50 of ~70 nM. CINPA1 can be used as a molecular tool for understanding CAR function[1].

Product Specifications

CAS Number

[102636-74-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Constitutive Androstane Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cinpa1.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CCN(CC)CC(N1C2=CC(NC(OCC)=O)=CC=C2CCC3=C1C=CC=C3)=O

Molecular Formula

C23H29N3O3

Molecular Weight

395.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Cherian MT, et al. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol Pharmacol. 2015 May;87 (5) :878-89.