VU0364289

VU0364289 is a highly selective mGlu5 positive allosteric modulator (PAM) (binds to the MPEP (HY-14609A) site), with an EC50 of 1.6 μM. VU0364289 can reverse amphetamine-induced hyperlocomotion in a dose-dependent manner, which can be used for schizophrenia and other psychiatric research[1][2][3].

Product Specifications

CAS Number

[1242443-29-3]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0364289.html

Purity

99.52

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC=CC=C1N2CCN(CC2)C(COCC3=CC=CC=C3)=O

Molecular Formula

C20H21N3O2

Molecular Weight

335.40

Precautions

H315, H319

References & Citations

[1]Gregory KJ, et al. N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement. J Pharmacol Exp Ther. 2013 Nov;347 (2) :438-57. |[2]Ya Zhou, et al. Discovery of N-Aryl Piperazines as Selective mGluR5Potentiators with Improved In Vivo Utility. ACS medicinal chemistry letters, 2010, 1 (8) : 433-438.|[3]Psychosis Models[M]//Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, New Delhi, 2016: 731-750.