CU-76
CU-76 is an inhibitor for human cyclic GMP-AMP synthase (hcGAS) with an IC50 of 0.24 μM. CU-76 selectively inhibits the DNA pathway in human cells, and can be used in autoimmune research[1].
Product Specifications
CAS Number
[2400954-58-5]
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cu-76.html
Purity
97.6
Smiles
O=C(C1=NC(N)=NC(NC2=CC(F)=C(I)C(F)=C2)=N1)OC
Molecular Formula
C11H8F2IN5O2
Molecular Weight
407.11
References & Citations
[1]Padilla-Salinas R, et al., Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors. J Org Chem. 2020 Feb 7;85 (3) :1579-1600.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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