Biotin-β-Amyloid (17-40)

Biotin-β-Amyloid (17-40) is a N-terminal-labelled biotinylated amyloid-β (1-40) peptide. β-Amyloid (17-40) is a 24-residue fragment of the Aβ protein via post-translational processing of amyloid precursor protein (APP) [1].

Product Specifications

UNSPSC

12352209

Target

Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/biotin-β-amyloid-17-40.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)NC(CCCC[C@H]3[C@]([H])([C@]([H])(CS3)N4)NC4=O)=O

Molecular Formula

C120H192N28O33S2

Molecular Weight

2619.20

References & Citations

[1]Ruitian Liu, et al. Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation. J Neurosci Res. 2004 Jan 15;75 (2) :162-71.|[2]J Näslund, et al. The metabolic pathway generating p3, an A beta-peptide fragment, is probably non-amyloidogenic. Biochem Biophys Res Commun. 1994 Oct 28;204 (2) :780-7