JJC8-088 (dioxalate)

JJC8-088 dioxalate is the dioxalate salt form of JJC8-088 (HY-158013) . JJC8-088 dioxalate is a derivative of modafinil. JJC8-088 dioxalate is an inhibitor for dopamine transporter (DAT) . JJC8-088 dioxalate exhibits behavioral characteristics similar to cocaine in rat models, and can be to study psychostimulant use disorders[1].

Product Specifications

CAS Number

[2068692-71-5]

UNSPSC

12352005

Target

Dopamine Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jjc8-088-dioxalate.html

Purity

99.73

Solubility

DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

O=S(C(C1=CC=C(C=C1)F)C2=CC=C(C=C2)F)CCN3CCN(CC3)CC(CC4=CC=CC=C4)O.O=C(O)C(O)=O.O=C(O)C(O)=O

Molecular Formula

C32H36F2N2O10S

Molecular Weight

678.70

References & Citations

[1]Newman AH, et al., Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology. 2019 Jul;44 (8) :1435-1444. |[2]Tunstall BJ, et al. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 2018 Mar 15;131:96-103.