SAMβA
SAMβA is conjugated to the cell permeable peptide TAT47-57. SAMβA, a rationally designed selective antagonist of Mfn1-βIIPKC association. SAMβA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats[1].
Product Specifications
CAS Number
2429946-75-6
UNSPSC
12352209
Target
PKC
Type
Peptides
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/samβa.html
Solubility
10 mM in DMSO
Smiles
OC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O
Molecular Formula
C50H73N17O16
Molecular Weight
1168.22
References & Citations
[1]Julio C B Ferreira A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun. 2019 Jan 18;10 (1) :329.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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