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SAMβA

SAMβA is conjugated to the cell permeable peptide TAT47-57. SAMβA, a rationally designed selective antagonist of Mfn1-βIIPKC association. SAMβA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats[1].

Product Specifications

CAS Number

2429946-75-6

UNSPSC

12352209

Target

PKC

Type

Peptides

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/samβa.html

Solubility

10 mM in DMSO

Smiles

OC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O

Molecular Formula

C50H73N17O16

Molecular Weight

1168.22

References & Citations

[1]Julio C B Ferreira A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun. 2019 Jan 18;10 (1) :329.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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