Temanogrel (hydrochloride)
Product Specifications
UNSPSC Description
Temanogrel hydrochloride is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/temanogrel-hydrochloride.html
Smiles
O=C(C1=CC(OC)=CC=C1)NC2=CC(C3=CC=NN3C)=C(OCCN4CCOCC4)C=C2.Cl
Molecular Weight
472.96
References & Citations
[1]Xiong Y, et al. Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis. J Med Chem. 2010 Jun 10;53(11):4412-21.|[2]Przyklenk K, et al. Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis. J Thromb Haemost. 2010 Feb;8(2):331-40.|[3]Adams JW, et al. APD791, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology. J Pharmacol Exp Ther. 2009 Oct;331(1):96-103.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10560A/Temanogrel-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10560A/
Clinical Information
Phase 2
CAS Number
957466-27-2
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