Temanogrel (hydrochloride)

Temanogrel hydrochloride is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.

Product Specifications

CAS Number

[957466-27-2]

Product Name Alternative

APD791 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/temanogrel-hydrochloride.html

Smiles

O=C(C1=CC(OC)=CC=C1)NC2=CC(C3=CC=NN3C)=C(OCCN4CCOCC4)C=C2.Cl

Molecular Formula

C24H29ClN4O4

Molecular Weight

472.96

References & Citations

[1]Xiong Y, et al. Discovery and structure-activity relationship of 3-methoxy-N- (3- (1-methyl-1H-pyrazol-5-yl) -4- (2-morpholinoethoxy) phenyl) benzamide (APD791) : a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis. J Med Chem. 2010 Jun 10;53 (11) :4412-21.|[2]Przyklenk K, et al. Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis. J Thromb Haemost. 2010 Feb;8 (2) :331-40.|[3]Adams JW, et al. APD791, 3-methoxy-n- (3- (1-methyl-1h-pyrazol-5-yl) -4- (2-morpholinoethoxy) phenyl) benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology. J Pharmacol Exp Ther. 2009 Oct;331 (1) :96-103.