EW-7195
EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung[1].
Product Specifications
CAS Number
[1352609-28-9]
UNSPSC
12352005
Target
P38 MAPK; TGF-β Receptor
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ew-7195.html
Purity
98.84
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=CC=CC(NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2)=C1
Molecular Formula
C23H18N8
Molecular Weight
406.44
References & Citations
[1]Park CY, et al. EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung. Eur J Cancer. 2011;47 (17) :2642-2653.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK5; p38α
Available Sizes
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