EW-7195

EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α. EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung[1].

Product Specifications

CAS Number

[1352609-28-9]

UNSPSC

12352005

Target

P38 MAPK; TGF-β Receptor

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ew-7195.html

Purity

98.84

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#CC1=CC=CC(NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2)=C1

Molecular Formula

C23H18N8

Molecular Weight

406.44

References & Citations

[1]Park CY, et al. EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung. Eur J Cancer. 2011;47 (17) :2642-2653.