JAK1-IN-13
JAK1-IN-13 (compound 36b) is an orally active, potent and highly selective inhibitor of JAK1 with an IC50 of 0.044 nM. JAK1-IN-13 significantly decreases STAT3 phosphorylation[1].
Product Specifications
CAS Number
[2778330-90-6]
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak1-in-13.html
Purity
98.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N[C@@H]2C[C@@H](N(CC2)CC3=CC=C(C=C3)C(F)(F)F)C)C4=C(NC=C4)N=C1)NC
Molecular Formula
C23H26F3N5O
Molecular Weight
445.48
References & Citations
[1]Park E, et al. Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis. J Med Chem. 2023 Dec 14;66 (23) :16342-16363.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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