SC-514

SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

Product Specifications

CAS Number

[354812-17-2]

Product Name Alternative

GK 01140

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IKK

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SC-514.html

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=C(N)C=C(C2=CSC=C2)S1)N

Molecular Formula

C9H8N2OS2

Molecular Weight

224.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Kishore N, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem. 2003 Aug 29;278 (35) :32861-71.|[2]Tse AK, et al. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017 Apr;11:562-576.