5-Carboxy-2′-deoxyuridine
5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine[1]. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine[2].
Product Specifications
CAS Number
14599-46-3
UNSPSC
12352204
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite
Type
Enzyme
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/5-carboxy-2-deoxyuridine.html
Purity
98.98
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O[C@H]1C[C@H](N2C(NC(C(C(O)=O)=C2)=O)=O)O[C@@H]1CO
Molecular Formula
C10H12N2O7
Molecular Weight
272.21
Precautions
H302, H315, H319, H335
References & Citations
[1]V Guerniou, et al. New synthesis of 5-carboxy-2'-deoxyuridine and its incorporation into synthetic oligonucleotides. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22 (5-8) :1073-5.|[2]D Pavan-Langston, et al. Intraocular penetration of trifluridine. Am J Ophthalmol. 1979 Jun;87 (6) :814-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Enzyme
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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