5-Carboxy-2′-deoxyuridine

5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine[1]. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine[2].

Product Specifications

CAS Number

[14599-46-3]

UNSPSC

12352204

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Enzyme

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/5-carboxy-2-deoxyuridine.html

Purity

98.98

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O[C@H]1C[C@H](N2C(NC(C(C(O)=O)=C2)=O)=O)O[C@@H]1CO

Molecular Formula

C10H12N2O7

Molecular Weight

272.21

Precautions

H302, H315, H319, H335

References & Citations

[1]V Guerniou, et al. New synthesis of 5-carboxy-2'-deoxyuridine and its incorporation into synthetic oligonucleotides. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22 (5-8) :1073-5.|[2]D Pavan-Langston, et al. Intraocular penetration of trifluridine. Am J Ophthalmol. 1979 Jun;87 (6) :814-8.